Cryptococcal Antigen Screening in Uganda Etiologies of Meningitis in Africa Cape Town, South Africa Учебный сайт
Учебные материалы


Cryptococcal Antigen Screening in Uganda Etiologies of Meningitis in Africa





Cryptococcal Antigen Screening in Uganda


Etiologies of Meningitis in Africa

Cape Town, South Africa







Long Term Survival in Kampala



Cost Effectiveness





  • Conversely, the cost of hospitalization and 14 days of amphotericin for treatment of cryptococcal meningitis is:

    • $425 per episode in Uganda [WEPE028]
    • $2883 per episode in South Africa
  • Thus for the treatment costs of 1 cryptococcal meningitis episode, one could perform CRAG LFA screening on:

    • 170 persons in Uganda
    • 1153 persons in South Africa.
  • Above a CRAG+ prevalence of 1%, pre-ART CRAG screening is Cost Saving compared to the cost of any Cryptococcal Meningitis treatment



CrAg Screening concept is great, but will it work in the real world?



ORCAS Trial

  • Operational Research in CrAg Screening

  • Multisite CrAg Screening Project in Uganda

  • Implementation Science

  • Stepped Wedge Design, RCT

  • Roll out over 2 years





CrAg Roll Out



Design



ORCAS Endpoints

  • Primary: 6-month Survival

  • Secondary:

    • Cryptococcal meningitis free survival time
    • Uptake of screening & pre-emptive treatment
    • Cost Effectiveness
    • Concordance between LFA & latex, other body fluids


Multiple ORCAS Partners

  • Infectious Disease Institute

    • David Meya, Radha Rajasingham, Yuka Manabe
  • University of Minnesota

    • David Boulware, Melissa Rolfes, Josh Rhein
  • CDC and CDC-Uganda

    • Jonathan Kaplan, Emmy Bangizi Muramuzi, Anthony Mukasa Mubiru, Ben Park, et al.

Карта сайта

Последнее изменение этой страницы: 2018-09-09;



2010-05-02 19:40
referat 2018 год. Все права принадлежат их авторам! Главная